N-丁基-5-硝基-2-(2-丙炔基氧基)苯甲酰胺合成路线 （共 3 条）
反应条件
sodium tetrahydroborate; palladium 10 on activated carbon in methanol; water T=20°C; Inert atmosphere;
参考文献
Fiorino, Ferdinando; Eiden, Martin; Giese, Armin; Severino, Beatrice; Esposito, Antonella; Groschup, Martin H.; Perissutti, Elisa; Magli, Elisa; Incisivo, Giuseppina Maria; Ciano, Antonio; Frecentese, Francesco; Kretzschmar, Hans A.; Wagner, Jens; Santagada, Vincenzo; Caliendo, Giuseppe
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5001 - 5011
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene
T=40°C; 0.5 h; other catalysts, other NaOH concentrations, other solvents and reaction time; Product distribution;
参考文献
Nisato, Dino; Frigerio, Marco; Boccardi, Giovanni; Palmisano, Giovanni
Synthesis, 1982 , # 12 p. 1081 - 1083
反应条件
1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C
3.1: sodium hydride / 1,4-dioxane; mineral oil / 2 h / 70 °C / Cooling with ice; Inert atmosphere
3.2: 4 h / 70 °C / Inert atmosphere
View Scheme
参考文献
Fiorino, Ferdinando; Eiden, Martin; Giese, Armin; Severino, Beatrice; Esposito, Antonella; Groschup, Martin H.; Perissutti, Elisa; Magli, Elisa; Incisivo, Giuseppina Maria; Ciano, Antonio; Frecentese, Francesco; Kretzschmar, Hans A.; Wagner, Jens; Santagada, Vincenzo; Caliendo, Giuseppe
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5001 - 5011
