2-乙基-2,4,4,4-四氟-3-氧代丁酸酯合成路线 （共 11 条）
参考文献
McBee et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 3152
参考文献
McBee et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 3152
反应条件
1: diisopropyl(carboethoxyfluoromethyl)phosphonate With n-butyllithium in tetrahydrofuran
T=-78°C; 0.333333 h;
2: trifluoroacetic acid trimethylsilyl ester in tetrahydrofuran
T=-78 - 20°C;
3: With hydrogenchloride in tetrahydrofuran
Further stages.;
参考文献
Tsai, Hou-Jen; Hsieh, Chi-Wei
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 749 - 757
反应条件
1: in tetrahydrofuran
2: With hydrogenchloride in tetrahydrofuran
Further stages.;
参考文献
Tsai, Hou-Jen; Hsieh, Chi-Wei
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 749 - 757
反应条件
sodium hydrogencarbonate in water
Yield given;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Tetrahedron Letters, 1989 , vol. 30, # 45 p. 6113 - 6116
反应条件
1: diisopropyl(carboethoxyfluoromethyl)phosphonate With n-butyllithium in tetrahydrofuran
T=-78°C;
2: trifluoroacetic acid chloride in tetrahydrofuran
T=-78 - 20°C;
3: anhydrous potassium trimethylsilanolate in tetrahydrofuran
T=20°C; 10 h; Further stages.;
参考文献
Tsai, Hou-Jen; Hsieh, Chi-Wei
Journal of the Chinese Chemical Society, 2007 , vol. 54, # 3 p. 749 - 757
参考文献
AIR PRODUCTS AND CHEMICALS, INC.
Patent: EP1174415 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane
1.) -78 deg C, 20 min, 2.) 40-45 deg C, 18 h;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Journal of Fluorine Chemistry, 1996 , vol. 77, # 1 p. 45 - 50
反应条件
n-butyllithium
1.) THF, -78 deg C, 20 min, 2.) THF, RT, 5 h; Yield given. Multistep reaction;
参考文献
Tsai, Hou-Jen
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 126, p. 1 - 10
反应条件
anhydrous potassium trimethylsilanolate
10 h; Ambient temperature;
参考文献
Tsai, Hou-Jen
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 126, p. 1 - 10
