N-(4-(氨基磺酰基)-2-氯苯基)-乙酰胺合成路线 （共 5 条）
反应条件
hydrogenchloride 0.75 h; Heating;
参考文献
MERCK and CO., INC.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
Patent: WO2005/115147 A2, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: aq. HCl / 0.75 h / Heating 2: aq. HCl; H2O2 / 1.08 h / 50 - 80 °C View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
ammonium hydroxide
T=70°C; 0.5 h;
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: chlorosulfonic acid / 3.5 h / 70 - 80 °C
2: aq. NH4OH / 0.5 h / 70 °C
View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
1: 100 percent / 0.5 h / Heating
2: chlorosulfonic acid / 3.5 h / 70 - 80 °C
3: aq. NH4OH / 0.5 h / 70 °C
View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
