2-甲酸甲酯-3-氰基噻吩合成路线 （共 2 条）
反应条件
1: methyl 3-aminothiophene-2-carboxylate With sodium nitrite in hydrogenchloride
T=0 - 4°C;
2: sodium cyanide in water
T=25°C; 1 h;
参考文献
Kaizerman, Jacob A.; Gross, Matthew I.; Ge, Yigong; White, Sarah; Hu, Wenhao; Duan, Jian-Xin; Baird, Eldon E.; Johnson, Kirk W.; Tanaka, Richard D.; Moser, Heinz E.; Buerli, Roland W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3914 - 3929
反应条件
potassium hydroxide in ethanol
0.75 h;
参考文献
Kaizerman, Jacob A.; Gross, Matthew I.; Ge, Yigong; White, Sarah; Hu, Wenhao; Duan, Jian-Xin; Baird, Eldon E.; Johnson, Kirk W.; Tanaka, Richard D.; Moser, Heinz E.; Buerli, Roland W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3914 - 3929
