4-(二甲基氨基)-2-氧代丁-3-烯酸乙酯合成路线 （共 5 条）
参考文献
CHEMOCENTRYX, INC.; CHEN, Xi; FAN, Pinchen; GLEASON, Mark, M.; JAEN, Juan, C.; LI, Lianfa; MCMAHON, Jeffrey, P.; POWERS, Jay; ZENG, Yibin; ZHANG, Penglie
Patent: WO2010/54006 A1, 2010 ;
Location in patent: Page/Page column 59 ;
WO 2010/054006 A1
参考文献
Riley; Hennen; Dalley; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 4 p. 955 - 964
反应条件
hydraziniumdihydrochloride in ethanol T=20°C; Reflux;
参考文献
CHEMOCENTRYX, INC.; CHEN, Xi; FAN, Pinchen; GLEASON, Mark, M.; JAEN, Juan, C.; LI, Lianfa; MCMAHON, Jeffrey, P.; POWERS, Jay; ZENG, Yibin; ZHANG, Penglie
Patent: WO2010/54006 A1, 2010 ;
Location in patent: Page/Page column 59 ;
WO 2010/054006 A1
反应条件
1: 4-(4-chloro-2-fluorophenoxy)benzamidine With sodium ethanolate in ethanol Heating / reflux; 2: 4-dimethylamino-2-oxo-but-3-enoic acid methyl ester; ethyl 4-(dimethylamino)-2-oxo-3-butenoate in ethanol 21 h; Heating / reflux; 3: With sulfuric acid in ethanol 3 h; Heating / reflux;
参考文献
EURO-CELTIQUE S.A.
Patent: WO2004/111011 A2, 2004 ;
Location in patent: Page 24; 25 ;
