4-羧基-alpha-甲基苯乙酸合成路线 （共 3 条）
反应条件
1: With water; sodium hydroxide in methanol
T=20°C; 8 h;
2: With hydrogenchloride in water
pH=2;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeon-Seop
Patent: WO2010/127856 A1, 2010 ;
Location in patent: Page/Page column 94; 95 ;
反应条件
potassium hydroxide; polyethylene glycol (PEG-400); potassium cyanide; nickel cyanide; cobalt(II) chloride in toluene
T=90°C; P=760 Torr; 24 h;
参考文献
Lee, Jong-Tae; Alper, Howard
Tetrahedron Letters, 1991 , vol. 32, # 15 p. 1769 - 1770
反应条件
alkaline permanganate
参考文献
Errera
Gazzetta Chimica Italiana, 1891 , vol. 21 I, p. 98
