2-羟基-4-甲氧基苯甲醛合成路线 （共 227 条）
反应条件
1: K2CO3 / butan-2-one / 7 h / Heating 2: 1N aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
反应条件
potassium carbonate; butanone Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Tanaka
Journal of the American Chemical Society, 1951 , vol. 73, p. 872
反应条件
Mont KSF; hydroxylamine hydrochloride; silica gel 0.0666667 h; microwave irradiation;
参考文献
Dewan, Sharwan K.; Singh, Ravinder; Kumar, Anil
Synthetic Communications, 2004 , vol. 34, # 11 p. 2025 - 2029
反应条件
sodium acetate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
参考文献
Hoffmann-La Roche Inc.
Patent: US6617346 B1, 2003 ;
反应条件
1.1: 74 percent / AcOH; NH4OAc 2.1: 81 percent / NaBH4 / propan-2-ol; tetrahydrofuran / 20 °C 3.1: aq. NaOH / 0.5 h / 20 °C 3.2: 64 percent / aq. H2SO4 / 0 - 20 °C View Scheme
参考文献
Tanaka
Journal of the American Chemical Society, 1951 , vol. 73, p. 872
反应条件
2: und Erwaermen des Reaktionsprodukts mit wss.NaOH 3: aqueous methanol. NaOH-solution View Scheme
参考文献
Raistrick; Robinson; White
Biochemical Journal, 1936 , vol. 30, p. 1303,1313
反应条件
potassium carbonate in N,N-dimethyl-formamide T=130°C; 8 h;
参考文献
Yamaguchi, Seiji; Takahashi, Koichi; Kawase, Yoshiyuki
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 759 - 761
反应条件
1: sodium; benzene / anschliessend mit 4-Brom-2-methyl-buten-(2) 2: sodium acetate / 160 °C View Scheme
参考文献
Spaeth; Holzen
Chemische Berichte, 1934 , vol. 67, p. 264
反应条件
1: 91 percent / NaOH / H2O / 1.) room temperature, 10 min, 2.) reflux, 15h 2: 1 percent / I2, Mg / tetrahydrofuran / 4 h / Heating 3: 98 percent / MnO2 / CHCl3 / 15 h / Heating View Scheme
参考文献
Cao, Zhisong; Liehr, Joachim G.
Synthetic Communications, 1996 , vol. 26, # 6 p. 1233 - 1245
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / |Large scale 1.2: 3 h / 175 °C / |Large scale 2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / |Reflux 2.2: |Reflux View Scheme
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KIM, Dong Jin; YOO, Kyung Ho; KIM, Young Soo; PARK, Woong Seo; KANG, Yong Koo; KIM, Hye Yun; KIM, Yun Kyung; PARK, Ki Duk; KIM, Maeng Sup; SUH, Kwee Hyun; AHN, Young Gil
Patent: WO2013/147568 A1, 2013 ;
