sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water; toluene T=0 - 95°C; 3 h;

1.1: magnesium; iodine / diethyl ether / 0.25 h / Heating 1.2: 57 percent / diethyl ether / 2 h / Heating 2.1: sodium hydride / dimethylformamide / 4.5 h / 70 - 80 °C View Scheme

1: With thionyl chloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane T=30 - 38°C; 2: With sodium carbonate in water; 1,2-dichloro-ethane; isobutyl methylketone T=22 - 25°C; pH=8.5 - 9.0; 0.5 h;