potassium tert-butylate in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;

1: With potassium tert-butylate in tetrahydrofuran T=0°C; 2 h; 2: With water; ammonium chloride in tetrahydrofuran 3: With lithium hydroxide hydrate; water in dimethyl sulfoxide T=20 - 70°C;

1: With methanol; sodium hydroxide; water in tetrahydrofuran 24 h; Heating / reflux; 2: With hydrogenchloride; water

potassium carbonate in acetone 24 h; Heating / reflux;

1: sulfuric acid / 120 h / Reflux 2: potassium carbonate / acetone / Reflux View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C 2.1: sodium tetrahydroborate; methanol / 4 h / 0 - 20 °C 3.1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C 4.1: triphenylphosphine; water / tetrahydrofuran / 50 °C 4.2: 0.08 h / 20 °C 5.1: sodium hydrogencarbonate; sodium hydroxide / water / pH 9 View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C 2.1: sodium tetrahydroborate; methanol / 4 h / 0 - 20 °C 3.1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C 4.1: triphenylphosphine; water / tetrahydrofuran / 50 °C 4.2: 0.08 h / 20 °C View Scheme

potassium tert-butylate in tetrahydrofuran T=0°C; 2 h; Inert atmosphere;

1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C 2: sodium tetrahydroborate; methanol / 4 h / 0 - 20 °C View Scheme