二氟溴乙酸乙酯合成路线

参考文献

WO2013/4984 A1, ;

Page/Page column 68 ;

参考文献

Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200

109-04-6邻溴吡啶

267876-28-82,2-二氟-2-(2-吡啶)乙酸乙酯

参考文献

Dolling, Ulf H.; Alabaster, Ramon; Ashwood, Michael S.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Patent: US2002/103379 A1, 2002 ;

109-04-6邻溴吡啶

267876-28-82,2-二氟-2-(2-吡啶)乙酸乙酯

参考文献

Dolling, Ulf H.; Alabaster, Ramon; Ashwood, Michael S.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Patent: US2002/103379 A1, 2002 ;

591-50-4碘苯+

667-27-6二氟溴乙酸乙酯

2248-46-6Alpha,Alpha-二氟苯乙酸乙酯

参考文献

Sato; Omote; Ando; Kumadaki
Journal of Fluorine Chemistry, 2004 , vol. 125, # 4 p. 509 - 515

667-27-6二氟溴乙酸乙酯

2248-46-6Alpha,Alpha-二氟苯乙酸乙酯

参考文献

Araki, Keisuke; Inoue, Munenori
Tetrahedron, 2013 , vol. 69, # 19 p. 3913 - 3918

667-27-6二氟溴乙酸乙酯+

98-80-6苯硼酸

2248-46-6Alpha,Alpha-二氟苯乙酸乙酯

参考文献

Feng, Zhang; Min, Qiao-Qiao; Xiao, Yu-Lan; Zhang, Bo; Zhang, Xingang
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1669 - 1673
Angew. Chem., 2014 , vol. 126, # 6 p. 1695 - 1699,5

667-27-6二氟溴乙酸乙酯+

4068-76-25-溴水杨酸甲酯

1131587-78-4

参考文献

INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; CLARK, Ryan, Christopher; TRUONG, Yen, Pham
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Location in patent: Paragraph 00294 ;

529-28-22-碘苯甲醚+

667-27-6二氟溴乙酸乙酯

1150164-80-92,2-二氟-2-(2-甲氧基苯基)乙酸乙酯

参考文献

Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique
Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651

75-77-4三甲基氯硅烷+

667-27-6二氟溴乙酸乙酯

205865-67-42-（三甲基硅基）-2，2-二氟乙酸乙酯

参考文献

Levin, Vitalij V.; Elkin, Pavel K.; Struchkova, Marina I.; Dilman, Alexander D.
Journal of Fluorine Chemistry, 2013 , vol. 154, p. 43 - 46