4,5-二氯-2-硝基苯胺合成路线 （共 26 条）
反应条件
1: sat. NaHCO3 / CH2Cl2 / Ambient temperature 2: 72 percent / benzyltriethylammonium chloride, aq. NaOH / toluene / Ambient temperature View Scheme
参考文献
Brown, Samuel A.; Rizzo, Carmelo J.
Synthetic Communications, 1996 , vol. 26, # 21 p. 4065 - 4080
反应条件
1: 98 percent / H2, Raney nickel / ethanol / 2068.6 Torr 2: 91 percent / H2O; methanol 3: CuBr2, tert-butyl nitrite / acetone / 2 h View Scheme
参考文献
Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262
反应条件
1: H2 / Raney Ni / tetrahydrofuran 2: H2O / Heating View Scheme
参考文献
Navarrete-Vazquez, Gabriel; Cedillo, Roberto; Hernandez-Campos, Alicia; Yepez, Lilian; Hernandez-Luis, Francisco; Valdez, Juan; Morales, Raul; Cortes, Rafael; Hernandez, Manuel; Castillo, Rafael
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 2 p. 187 - 190
反应条件
1: 98 percent / N-chlorosuccinimide / dimethylformamide / 1 h / 100 °C 2: 72 percent / iron powder; concd HCl / ethanol / 3.5 h / Heating View Scheme
参考文献
Gudmundsson, Kristjan S.; Tidwell, Jeffrey; Lippa, Nicole; Koszalka, George W.; van Draanen, Nanine; Ptak, Roger G.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2464 - 2472
反应条件
1: 98 percent / H2, Raney nickel / ethanol / 2068.6 Torr 2: 91 percent / H2O; methanol View Scheme
参考文献
Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262
参考文献
Beilstein; Kurbatow
Justus Liebigs Annalen der Chemie, 1879 , vol. 196, p. 222
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1879 , vol. 11, p. 332
参考文献
Beilstein; Kurbatow
Justus Liebigs Annalen der Chemie, 1879 , vol. 196, p. 222
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1879 , vol. 11, p. 332
反应条件
hydrogen; nickel in ethanol P=2068.6 Torr;
参考文献
Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262
反应条件
iron; ytterbium(III) triflate T=75°C; 3 h;
参考文献
Wang, Fen; Tran-Dube, Michelle; Scales, Stephanie; Johnson, Sarah; McAlpine, Indrawan; Ninkovic, Sacha
Tetrahedron Letters, 2013 , vol. 54, # 31 p. 4054 - 4057
反应条件
1: zinc; aqueous ethanol View Scheme
参考文献
Weygand et al.
Zeitschrift fuer Naturforschung, 1951 , vol. 6b, p. 25,33
