4,5-二氯-2-硝基苯胺合成路线 （共 26 条）
反应条件
methoxylamine hydrochloride; potassium tert-butylate; copper diacetate in ethylene glycol diethyl ether T=20°C; Substitution; Amination; 2 h;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 11 p. 1437 - 1444
反应条件
ammonia in water; isopropyl alcohol T=120°C; 6 h;
参考文献
Wollweber; Kolling; Niemers; et al.
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 5 p. 531 - 542
反应条件
sulfuric acid T=120°C;
参考文献
Journal of the Chemical Society, , p. 1842
反应条件
1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 3: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min 2: conc. sulfuric acid / 0.25 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 21, p. 421
Chemische Berichte, , vol. 37, p. 3892
反应条件
1: beim Nitrieren 2: alcohol; ammonia View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 21, p. 421
Chemische Berichte, , vol. 37, p. 3892
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 21, p. 421
Chemische Berichte, , vol. 37, p. 3892
参考文献
Justus Liebigs Annalen der Chemie, , vol. 196, p. 222
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 11, p. 332
反应条件
1: 2-nitro-4,5-dichloro-aniline With sodium hydride in DMF (N,N-dimethyl-formamide) 0.25 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2005/65680 A1, 2005 ;
Location in patent: Page/Page column 46 ;
WO 2005/065680 A1
