2,3-二氢-3-氧代-1,2-苯并异噻唑-2-乙酸甲酯1,1-二氧化物合成路线 （共 33 条）
反应条件
in DMF (N,N-dimethyl-formamide) T=115 - 120°C; 1.5 - 2 h; Industry scale;
参考文献
Venkataraman, Sundaram; Kumar, Muppa Kishore; Purandhar, Koilkonda; Reddy, Bairy Kondal; Reddy, Lekkala Amarnath; Kondaiah, Golla Chinamala; Sreenath, Keshaboina
Patent: US2006/25408 A1, 2006 ;
Location in patent: Page/Page column 1; 3 ;
参考文献
Nicolas, Colette; Verny, Michel; Giraud, Isabelle; Ollier, Monique; Rapp, Maryse; Maurizis, Jean-Claude; Madelmont, Jean-Claude
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5235 - 5240
反应条件
1: 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.166667 h; 2: chloroacetic acid methyl ester T=20 - 80°C; 3.5 h; Further stages.;
参考文献
Balssa, Frederic; Bonnaire, Yves
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 3 p. 207 - 210
反应条件
sodium hydride in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Berryman; Edmunds; Bunker; Haleen; Bryant; Welch; Doherty
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1447 - 1456
参考文献
Chemische Berichte, , vol. 30, p. 1268
反应条件
1: With sodium methylate in methanol T=55°C; 0.5 h; Inert atmosphere; 2: With hydrogenchloride in methanol; water pH=3; Cooling with ice;
参考文献
Ahmad, Naveed; Zia-Ur-Rehman, Muhammad; Siddiqui, Hamid Latif; Ullah, Muhammad Fasih; Parvez, Masood
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2368 - 2377
反应条件
in methanol 0.05 h; Heating;
参考文献
Schapira, Celia B.; Perillo, Isabel A.; Lamdan, Samuel
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1281 - 1288
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 1281 - 1288
反应条件
in tert-butyl alcohol
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 1281 - 1288
反应条件
2-methoxy-ethanol; sodium Yield given. Multistep reaction;
参考文献
Svoboda, Jiri; Palecek, Jaroslav; Dedek, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 5 p. 1133 - 1139
