lithium aluminium tetrahydride in tetrahydrofuran; water

sodium methylate in water; N,N-dimethyl-formamide

sodium borohydride in 1,4-dioxane; methanol

1: pyridine / 1 h / 0 °C 2: 6.53 percent / dimethylformamide / 2 h / 20 °C View Scheme

in N,N-dimethyl-formamide T=20°C; 2 h;

1.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 80 °C / |Large scale 1.2: 65 °C / |Large scale 1.3: 12 h / 75 °C / |Large scale 2.1: pyridine / dichloromethane / 1 h / -5 °C / |Inert atmosphere; |Reflux; |Large scale 2.2: 1 h / -5 °C / |Inert atmosphere; |Large scale 3.1: 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C / |Inert atmosphere; |Reflux; |Large scale 3.2: 0 °C / |Inert atmosphere; |Large scale View Scheme

1: K3PO4*3H2O / tetrahydrothiophene 1,1-dioxide / 2 h / 110 °C 2: 241 mg / Na2S*9H2O / tetrahydrothiophene 1,1-dioxide / 5 h / 120 °C 3: pyridine / 1 h / 0 °C 4: 6.53 percent / dimethylformamide / 2 h / 20 °C View Scheme

methanesulfonic acid in methanol

in methanol T=20 - 60°C; Large scale;