4-(2-硝基苯基)乙酰乙酸乙酯合成路线 （共 10 条）
反应条件
2: Na2S2O4; aqueous NaOH View Scheme
参考文献
Giuliano; Stein
Annali di Chimica (Rome, Italy), 1958 , vol. 48, p. 1284,1290
反应条件
ammonium chloride; zinc in tetrahydrofuran 2 h;
参考文献
Royer, Daniel; Wong, Yung-Sing; Ple, Sophie; Chiaroni, Angele; Diker, Khalid; Levy, Jean
Tetrahedron, 2008 , vol. 64, # 40 p. 9607 - 9618
反应条件
ammonia in ethanol
4 h; Ambient temperature;
参考文献
Palazzino; Cecchi; Colotta; Melani; Filacchioni
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 1 p. 71 - 75
反应条件
1: 2-(2-nitrophenyl)acetic acid With 1,1'-carbonyldiimidazole in acetonitrile
T=20°C; 0.25 h;
2: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile
T=20°C; 18 h; Further stages.;
参考文献
Attia, Mohamed I.; Gueclue, Deniz; Hertlein, Barbara; Julius, Justin; Witt-Enderby, Paula A.; Zlotos, Darius P.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 13 p. 2129 - 2137
参考文献
Royer, Daniel; Wong, Yung-Sing; Ple, Sophie; Chiaroni, Angele; Diker, Khalid; Levy, Jean
Tetrahedron, 2008 , vol. 64, # 40 p. 9607 - 9618
反应条件
1: i-Pr2NEt / CH2Cl2 / 1) 0 deg C, 1h, 2) RT, 1h
2: Heating
View Scheme
参考文献
Moody, Christopher J.; Rahimtoola, Kulsum F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 673 - 679
反应条件
1: SOCl2 / 50 °C
2: i-Pr2NEt / CH2Cl2 / 1) 0 deg C, 1h, 2) RT, 1h
3: Heating
View Scheme
参考文献
Moody, Christopher J.; Rahimtoola, Kulsum F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 673 - 679
反应条件
triethylamine; magnesium chloride
1.) CH3CN, RT, 2 h, 2.) CH3CN, a) RT, overnight, b) reflux, 2 h; Yield givenMultistep reaction;
参考文献
Mai, Antonello; Artico, Marino; Sbardella, Gianluca; Massa, Silvio; Novellino, Ettore; Greco, Giovanni; Loi, Anna Giulia; Tramontane, Enzo; Marongiu, Maria Elena; La Colla, Paolo
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 619 - 627
反应条件
thionyl chloride; N,N-dimethyl-formamide
1.) CH2Cl2, reflux, 2.) CH2Cl2, THF, 1 h, -65 deg C; Yield given. Multistep reaction;
参考文献
Firl, Joachim; Maier, Walter; Daake, Heinz
Liebigs Annalen der Chemie, 1989 , p. 469 - 476
反应条件
Heating; Yield given;
参考文献
Moody, Christopher J.; Rahimtoola, Kulsum F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 673 - 679
