2,3,4,9-四氢-1H-咔唑-8-羧酸合成路线 （共 9 条）
反应条件
in acetic acid 3.5 h; Heating / reflux;
参考文献
BIOVITRUM AB
Patent: WO2004/63156 A1, 2004 ;
Location in patent: Page 40 ;
WO 2004/063156 A1
反应条件
1: 75 percent / ethanol; H2O / 12 h / Heating 2: 1.) tert-butyllithium / 1.) a) hexane, pentane, -78 deg C, b) RT, 16 h, 2.) a) THF, -78 deg C, b) RT View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 4 p. 794 - 799
反应条件
tert.-butyl lithium 1.) a) hexane, pentane, -78 deg C, b) RT, 16 h, 2.) a) THF, -78 deg C, b) RT; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 4 p. 794 - 799
参考文献
Journal of the Chemical Society, , p. 4114
反应条件
acetic acid Fischer indole synthesis; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 6 p. 1745 - 1748
参考文献
Journal of the Chemical Society, , p. 809
参考文献
Journal of the Chemical Society, , p. 2870,2872
反应条件
1: 58 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 2 h / Heating 2: dimethylformamide / 20 °C 3: 1.40 g / dimethylformamide View Scheme
参考文献
Kamata, Junichi; Okada, Toshimi; Kotake, Yoshihiko; Niijima, Jun; Nakamura, Katsuji; Uenaka, Toshimitsu; Yamaguchi, Atsumi; Tsukahara, Kappei; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke; Yoshimatsu, Kentaro; Yoshino, Hiroshi; Sugumi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1071 - 1081
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in toluene
2 h; Heating;
参考文献
Kamata, Junichi; Okada, Toshimi; Kotake, Yoshihiko; Niijima, Jun; Nakamura, Katsuji; Uenaka, Toshimitsu; Yamaguchi, Atsumi; Tsukahara, Kappei; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke; Yoshimatsu, Kentaro; Yoshino, Hiroshi; Sugumi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1071 - 1081
