3-苄基-6-溴-2-氯喹啉合成路线 （共 12 条）
反应条件
in methanol 0.25 h; Heating;
参考文献
Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay
Tetrahedron, 2007 , vol. 63, # 2 p. 451 - 460
反应条件
8 h; Heating / reflux;
参考文献
CHATTOPADHYAYA, Jyoti; UPADHAYAYA, Ram Shankar
Patent: WO2009/91324 A1, 2009 ;
Location in patent: Page/Page column 23 ;
WO 2009/091324 A1
反应条件
trichlorophosphate
T=10 - 80°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/435 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=10°C;
2: N-(4-bromophenyl)-3-phenylpropanamide T=20 - 80°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/434 A1, 2007 ;
Location in patent: Page/Page column 36-37 ;
反应条件
trichlorophosphate in toluene
T=120°C; 0.5 h;
参考文献
Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay
Tetrahedron, 2007 , vol. 63, # 2 p. 451 - 460
反应条件
1: 79 percent / TFA / 60 °C
2: 100 percent / K2CO3 / acetone / 0.25 h / 60 °C
3: 97 percent / POCl3 / toluene / 0.5 h / 120 °C
View Scheme
参考文献
Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay
Tetrahedron, 2007 , vol. 63, # 2 p. 451 - 460
反应条件
1: pyridine / CH2Cl2 / 3 h / 20 °C
2: 75 percent / DABCO / tetrahydrofuran; H2O / 3 h / 20 °C
3: 79 percent / TFA / 60 °C
4: 100 percent / K2CO3 / acetone / 0.25 h / 60 °C
5: 97 percent / POCl3 / toluene / 0.5 h / 120 °C
View Scheme
参考文献
Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay
Tetrahedron, 2007 , vol. 63, # 2 p. 451 - 460
反应条件
1: 75 percent / DABCO / tetrahydrofuran; H2O / 3 h / 20 °C
2: 79 percent / TFA / 60 °C
3: 100 percent / K2CO3 / acetone / 0.25 h / 60 °C
4: 97 percent / POCl3 / toluene / 0.5 h / 120 °C
View Scheme
参考文献
Pathak, Richa; Madapa, Sudharshan; Batra, Sanjay
Tetrahedron, 2007 , vol. 63, # 2 p. 451 - 460
反应条件
1: thionyl chloride / Reflux
2: trichlorophosphate / chloroform / 10 °C / Reflux
View Scheme
参考文献
Zakrytoe Aktsionernoe Obschestvo "Pharm-Sintez"
Patent: EP2371819 A1, 2011 ;
反应条件
1: thionyl chloride / Reflux
2: trichlorophosphate / chloroform / 10 °C / Reflux
View Scheme
参考文献
Zakrytoe Aktsionernoe Obschestvo "Pharm-Sintez"
Patent: EP2371819 A1, 2011 ;
