(1R)-1,4-脱水-2-脱氧-1-(1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-赤式-戊糖醇合成路线 （共 25 条）
反应条件
1: 72 percent / triethylamine hydrofluoride / tetrahydrofuran / 3 h
2: 91 percent / LiCl / dimethylformamide / 100 - 110 °C
3: 62 percent / tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / Heating
View Scheme
参考文献
Pankiewicz; Watanabe; Takayanagi; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1703 - 1710
反应条件
1: 320 mg / NH3 / methanol / 0.5 h
2: 62 percent / tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / Heating
View Scheme
参考文献
Pankiewicz; Watanabe; Takayanagi; et al.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 6 p. 1703 - 1710
反应条件
1: 12.3 percent / 1.) α-acetoxyisobutyryl chloride, 2> tri-n-butyltin hydride, 2,2'-azobis<2-methylpropionitrile> / 1.) acetonitrile, 2 h, reflux, 2.) 1,2-dimethoxyethane, 48 h, reflux
2: 22 percent / 1.5 h / Heating
View Scheme
参考文献
Matsuda; Chu; Reichman; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3603 - 3609
参考文献
Matsuda; Chu; Reichman; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3603 - 3609
参考文献
Chu,C.K. et al.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 1119 - 1121
