6-溴苯并异恶唑-3-甲酸乙酯合成路线 （共 5 条）
反应条件
hydrogen; triethylamine; palladium 10 on activated carbon in ethanol T=0°C; 1 h;
参考文献
Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok
Patent: US2005/250808 A1, 2005 ;
Location in patent: Page/Page column 40 ;
US 20050250808 A1
反应条件
sodium ethanolate; isopentyl nitrite in ethanol
T=60°C; 2 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 72 ;
反应条件
sodium ethanolate in ethanol
T=60°C; 2 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/111038 A2, 2005 ;
Location in patent: Page/Page column 66-67 ;
WO 2005/111038 A2
反应条件
1: With sodium; isopentyl nitrite in ethanol
T=20 - 60°C; 19.5 h;
2: With hydrogenchloride in ethanol; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/10995 A1, 2004 ;
Location in patent: Page/Page column 49-50 ;
WO 2004/010995 A1
反应条件
isopentyl nitrite
T=20 - 60°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 26 ;
