3,4-双(甲氧基甲氧基)苯甲醛合成路线 （共 15 条）
反应条件
potassium hydroxide in ethanol T=20°C; Winget's condensation; 5 h;
参考文献
Lim, Soon Sung; Jung, Sang Hoon; Ji, Jun; Shin, Kuk Hyun; Keum, Sam Rok
Journal of Pharmacy and Pharmacology, 2001 , vol. 53, # 5 p. 653 - 668
反应条件
1: aq. KOH / ethanol / 5 h / 20 °C 2: aq. HCl / methanol / Heating View Scheme
参考文献
Sang, Hoon Jung; Soo, Young Park; Kim-Pak, Youngmi; Hong, Kyu Lee; Kyong, Soo Park; Kuk, Hyun Shin; Ohuchi, Kazuo; Shin, Hyun-Kyung; Sam, Rok Keum; Soon, Sung Lim
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 3 p. 368 - 371
反应条件
1.1: sodium hydroxide / ethanol / 0.08 h / 20 °C 1.2: 24 h / 20 °C 2.1: dihydrogen peroxide / water / 24 h / 20 °C 3.1: hydrogenchloride; water / methanol / 0.5 h / Reflux View Scheme
参考文献
Zhao, Xiaolong; Liu, Jie; Xie, Zhixiang; Li, Ying
Synthesis (Germany), 2012 , vol. 44, # 14 art. no. SS-2012-H0237-OP, p. 2217 - 2224
反应条件
1: With potassium hydroxide in methanol Aldol Condensation; 2: With dihydrogen peroxide Alkaline conditions; 3: With hydrogenchloride in methanol
参考文献
Sato, Mizuho; Murakami, Kazuma; Uno, Mayumi; Ikubo, Haruko; Nakagawa, Yu; Katayama, Sumie; Akagi, Ken-Ichi; Irie, Kazuhiro
Bioscience, Biotechnology and Biochemistry, 2013 , vol. 77, # 5 p. 1100 - 1103
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 4 h / 0 - 4 °C 2: dihydrogen peroxide; sodium hydroxide / methanol; water / 4 h / 20 °C 3: hydrogenchloride / methanol; water / 0.33 h / Reflux 4: K2S2O5 / ethanol / 100 °C View Scheme
参考文献
Pandurangan; Bose, Chinchu; Banerji
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5328 - 5330
反应条件
1: 88 percent / KOH / ethanol / 15 h / Ambient temperature 2: 77 percent / H2O2, NaOH / methanol / 19 h / Ambient temperature 3: 76 percent / HCl / methanol / 0.25 h / 50 °C View Scheme
参考文献
Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki
Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377
反应条件
1: potassium hydroxide / ethanol; water / 36 h / 20 °C / Inert atmosphere 2: water; sodium acetate / ethanol / 24 h / Reflux 3: pyridine; iodine / 6 h / 90 °C 4: hydrogenchloride; water / tetrahydrofuran; methanol / 6 h / 50 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 12 p. 5949 - 5958
反应条件
sodium hydroxide in methanol; ethyl acetate
参考文献
Wang, Bing; Zhang, Yong-Kang; Chen, Jian; Zhang, Wei; Song, Jiangao; Del Balzo, Ughetta; Brown, Lesley; Boddupalli, Sekhar; Bobzin, Steven; Gilat, Sylvain; Miller, Guy
Patent: US2003/73712 A1, 2003 ;
反应条件
1: potassium hydroxide / methanol; water / 24 h / 20 °C 2: hydrogenchloride / methanol; water / 1 h View Scheme
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 74, # 4 p. 741 - 745
反应条件
potassium carbonate in acetone
T=20°C;
参考文献
Wang, Yanming; Mathis, Chester A.; Huang, Guo-Feng; Holt, Daniel P.; Debnath, Manik L.; Klunk, William E.
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 8 p. 647 - 664
