3-氧代-2,3-二氢哒嗪-4-甲腈合成路线 （共 6 条）
反应条件
1: in ethanol; water T=40°C; 0.5 h; 2: With sodium hydroxide; water in ethanol T=40 - 60°C; pH=12 - 13; 4 h; 3: With hydrogenchloride; water in ethanol pH=1 - 2;
参考文献
Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos G.; Peters, Jens-Uwe; Ricklin, Fabienne
Patent: US2008/234277 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080234277 A1
反应条件
ethanol Beim anschliessenden Erwaermen mit Essigsaeure und Piperidin bei pH 10;
参考文献
Helvetica Chimica Acta, , vol. 37, p. 134,139
反应条件
1: With sulfuric acid T=100°C; 2: With sodium carbonate
参考文献
Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos G.; Peters, Jens-Uwe; Ricklin, Fabienne
Patent: US2008/234277 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080234277 A1
反应条件
hydrogenchloride 1) THF, 20 h, r.t. 2) 10 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Haider, Norbert; Heinisch, Gottfried; Moshuber, Joeran
Tetrahedron, 1991 , vol. 47, # 40 p. 8573 - 8578
反应条件
sulfuric acid; water
参考文献
Schmidt; Druey
Helvetica Chimica Acta, 1954 , vol. 37, p. 134,139
