1,2-二溴-4,5-二氟苯合成路线 （共 8 条）
反应条件
bromine in monofluoro-trichloromethane Irradiation; Yields of byproduct given;
参考文献
Bolton, Roger; Owen, Elaine S. E.
Journal of Fluorine Chemistry, 1990 , vol. 46, # 3 p. 393 - 406
反应条件
bromine; iron Heating;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
反应条件
n-butyllithium in diethyl ether; hexane 1.) -78 deg C, 30 min; Yield given. Yields of byproduct given;
参考文献
Yarwood, Thomas David; Waring, Anthony John; Coe, Paul Leslie
Journal of Fluorine Chemistry, 1996 , vol. 78, # 2 p. 113 - 119
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine; triphenylphosphine in toluene T=85°C; Sonogashira cross-coupling; Inert atmosphere;
参考文献
Kane, Christopher M.; Meyers, Tiffany B.; Yu, Xin; Gerken, Michael; Etzkorn, Markus
European Journal of Organic Chemistry, 2011 , # 16 p. 2969 - 2980
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); polymethylhydroxysilane in N,N-dimethyl acetamide T=100°C; 3 h;
参考文献
Iqbal, Zafar; Lyubimtsev, Alexey; Hanack, Michael
Synlett, 2008 , # 15 p. 2287 - 2290
反应条件
1: Pd(PPh3)4, 2 M aq. Na2CO3 / toluene; ethanol / 3 h / Heating 2: 3-chloroperoxybenzoic acid / CH2Cl2 / 0.5 h / Ambient temperature 3: Pd(PPh3)4, 2 M aq. Na2CO3 / toluene; ethanol / 10 h / Heating View Scheme
参考文献
Li, James J.; Norton, Monica B.; Reinhard, Emily J.; Anderson, Gary D.; Gregory, Susan A.; Isakson, Peter C.; Koboldt, Carol M.; Masferrer, Jaime L.; Perkins, William E.; Seibert, Karen; Zhang, Yan; Zweifel, Ben S.; Reitz, David B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1846 - 1856
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
Suzuki Coupling; 40 h; Inert atmosphere;
参考文献
Dong, Cheng-Guo; Hu, Qiao-Sheng
Synlett, 2012 , vol. 23, # 14 p. 2121 - 2125
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine; triphenylphosphine in toluene
T=85°C; Sonogashira cross-coupling; Inert atmosphere;
参考文献
Kane, Christopher M.; Meyers, Tiffany B.; Yu, Xin; Gerken, Michael; Etzkorn, Markus
European Journal of Organic Chemistry, 2011 , # 16 p. 2969 - 2980
