(Z)-alpha-(甲氧基亚胺)-2-(三苯甲基氨基)噻唑-4-乙酸乙酯合成路线 （共 12 条）
反应条件
sodium hydroxide in 1,4-dioxane; dichloromethane; water
参考文献
Roussel Uclaf
Patent: US4202893 A1, 1980 ;
反应条件
sodium hydroxide in 1,4-dioxane 0.5 h; Heating;
参考文献
Sakagami; Atsumi; Yamamoto; Tamura; Yoshida; Nishihata; Fukatsu
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2433 - 2436
反应条件
1: aq. NaOH / dioxane / 0.5 h / Heating 2: (i) DCC, CH2Cl2, (ii) /BRN= 1081573/, Et3N, (iii) aq. HCO2H View Scheme
参考文献
Bucourt,R. et al.
Tetrahedron, 1978 , vol. 34, p. 2233 - 2243
反应条件
1: aq. NaOH / dioxane / 0.5 h / Heating 2: (i) DCC, CH2Cl2, (ii) /BRN= 622638/, Et3N, (iii) aq. HCO2H View Scheme
参考文献
Bucourt,R. et al.
Tetrahedron, 1978 , vol. 34, p. 2233 - 2243
反应条件
1: 1N NaOH / methanol 2: 632 mg / POCl3, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 3: 95 mg / CF3CO2H, anisole / 1 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 9 p. 2433 - 2436
反应条件
1: 1N NaOH / methanol 2: 632 mg / POCl3, pyridine / CH2Cl2 / 2 h / -20 - -10 °C 3: 95 mg / CF3CO2H, anisole / 1 h / 0 °C 4: 25 mg / dimethylformamide / 1 h / -20 °C View Scheme
参考文献
Sakagami; Atsumi; Yamamoto; Tamura; Yoshida; Nishihata; Fukatsu
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2433 - 2436
反应条件
triethylamine in N,N-dimethyl-formamide
3 h;
参考文献
Bucourt,R. et al.
Tetrahedron, 1978 , vol. 34, p. 2233 - 2243
反应条件
triethylamine in methanol; dichloromethane; water
参考文献
Roussel Uclaf
Patent: US4196205 A1, 1980 ;
反应条件
triethylamine in methanol; dichloromethane; water
参考文献
Roussel Uclaf
Patent: US4152432 A1, 1979 ;
反应条件
in dimethylsulfoxide (DMSO)
参考文献
Bristol-Myers Company
Patent: US4406899 A1, 1983 ;
