4-苯基吡咯-3-甲酸乙酯合成路线 （共 10 条）
反应条件
1: 4-toluene-sulfonylmethyl isocyanide With lithium hexamethyldisilazane in tetrahydrofuran T=78°C; 1.5 h; 2: benzalacetic acid ethyl ester in tetrahydrofuran T=25°C; 5.33 h;
参考文献
US6982265 B1, ;
Page/Page column 31 ;
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester; benzaldehyde With potassium tert-butylate in tetrahydrofuran 2 h; 2: tosylmethylisocyanate With potassium tert-butylate in tetrahydrofuran 3 h;
参考文献
WO2007/58504 A1, ;
Page/Page column 53 ;
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide 2 h; Ambient temperature;
参考文献
Farmaco, , vol. 45, # 7-8 p. 833 - 846
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide T=20°C; Cycloaddition; 0.0833333 h;
参考文献
Medicinal Chemistry Research, , vol. 7, # 2 p. 98 - 108
反应条件
sodium hydroxide in ethanol a) 0 deg C, 1 h, b) 20 deg C, 1 h;
参考文献
Journal of Organic Chemistry, , vol. 57, # 8 p. 2245 - 2249
反应条件
sodium hydride in diethyl ether T=20°C; 0.833333 h;
参考文献
Medicinal Chemistry Research, , vol. 11, # 3 p. 153 - 167
反应条件
1: K2CO3 2: sodium hydride / diethyl ether; various solvent(s) / 0.83 h / 20 °C View Scheme
参考文献
Medicinal Chemistry Research, , vol. 11, # 3 p. 153 - 167
反应条件
sodium 1) EtOH, 2) r.t.; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 57, # 8 p. 2245 - 2249
反应条件
sodium Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 57, # 8 p. 2245 - 2249
反应条件
1: 94 percent / potassium carbonate / dimethylformamide / 18 h / 90 °C 2: 91 percent / aq. sodium hydroxide / aq. ethanol / 3 h / Heating View Scheme
参考文献
Massa; Di Santo; Mai; Botta; Artico; Panico; Simonetti
Farmaco, 1990 , vol. 45, # 7-8 p. 833 - 846
