3,4,5-三甲氧基苯酚合成路线 （共 94 条）
参考文献
Journal of the Chemical Society, , p. 1029
反应条件
Eintraegen die Diazoniumsalzloesung in siedend heisse 50prozentige Schwefelsaeure;
参考文献
Gazzetta Chimica Italiana, , vol. 27 II, p. 354
反应条件
1: BF3-Et2O / 0.25 h 2: KOH / ethanol 3: 87 percent / I2; DMSO / 2 h / Heating 4: 89 percent / HBr; glacial AcOH / 18 h / Heating View Scheme
参考文献
Huang, Wen-Hsin; Chien, Pei-Yu; Yang, Ching-Huey; Lee, An-Rong
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 339 - 340
反应条件
1: BF3-Et2O / 0.25 h 2: KOH / ethanol 3: 87 percent / I2; DMSO / 2 h / Heating 4: 88 percent / HBr; glacial AcOH / 2 h / Heating View Scheme
参考文献
Huang, Wen-Hsin; Chien, Pei-Yu; Yang, Ching-Huey; Lee, An-Rong
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 339 - 340
反应条件
potassium carbonate in acetonitrile T=80°C;
参考文献
Jensen; Ager; Bliss; Canfield; Kotecka; Rieckmann; Terpinski; Jacobus
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3925 - 3931
反应条件
1: With zinc(II) chloride in nitromethane Friedel-Crafts reaction; 2: With sodium hydrogencarbonate in nitromethane Further stages.;
参考文献
Igarashi, Yasushi; Kumazawa, Hiroaki; Ohshima, Toshihoro; Satomi, Hisanori; Terabayashi, Susumu; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 9 p. 1088 - 1091
反应条件
1: 3,4,5-trimethoxyphenol With boron trifluoride diethyl etherate 0.25 h; Heating / reflux; 2: benzaldehyde With potassium hydroxide in ethanol; water T=15 - 20°C; 8 h; 3: With hydrogenchloride in water
参考文献
Unitech Pharmaceuticals, Inc.
Patent: US2004/242907 A1, 2004 ;
Location in patent: Page 2 ;
反应条件
1: 3,4,5-trimethoxyphenol; acetic anhydride With bismuth trifluoromethanesulphonate in toluene T=20°C; 0.0833333 h; Inert atmosphere; 2: isoprene in toluene T=40°C; 4 h; Inert atmosphereSealed tube; 3: With methanol; potassium carbonate T=20°C; 0.833333 h;
参考文献
Judd, Katie E.; Caggiano, Lorenzo
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 14 p. 5201 - 5210
反应条件
1: 96 percent / AcONa / 3 h / 110 °C 2: 94 percent / BF3*Et2O / 2 h / 70 °C View Scheme
参考文献
Oliverio; Bargellini
Gazzetta Chimica Italiana, 1948 , vol. 78, p. 386,394
参考文献
Huang, Wen-Hsin; Chien, Pei-Yu; Yang, Ching-Huey; Lee, An-Rong
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 339 - 340
