1,2,4,5-四羟基苯合成路线 （共 16 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Wessig, Pablo; Moellnitz, Kristian
Journal of Organic Chemistry, 2008 , vol. 73, # 12 p. 4452 - 4457
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 96 h; Yield given;
参考文献
Keegstra, Erik M. D.; Huisman, Bart-Hendrik; Paardekooper, Elizabeth M.; Hoogesteger, Frans J.; Zwikker, Jan W.; Jenneskens, Leonardus W.; Kooijman, Huub; Schouten, Arie; Veldman, Nora; Spek, Anthony L.
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 2, p. 229 - 240
反应条件
1.1: pyridinium p-toluenesulfonate / toluene / 15 h / |Dean-Stark; |Reflux 2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere 2.2: 0.17 h / -10 - 25 °C / |Inert atmosphere 3.1: hydrogenchloride / 1,4-dioxane; water / 8 h / |Reflux View Scheme
参考文献
Chen, Fanglei; Zhang, Guiping; Hong, Zebin; Lin, Zhonghui; Lei, Min; Huang, Mingdong; Hu, Lihong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2379 - 2382
反应条件
T=180°C; 1 h; Inert atmosphereSealed tube;
参考文献
Xerox Corporation
Patent: US2012/165529 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium hydroxide in dimethyl sulfoxide T=22 - 25°C; 0.583333 h;
参考文献
Johnson, Martin R.; Seok, Won K.; Ma, Wuping; Slebodnick, Carla; Wilcoxen, Keith M.; Ibers, James A.
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3298 - 3303
反应条件
1: 31 percent / KOH / dimethylsulfoxide / 0.58 h / 22 - 25 °C 2: 98 percent / KOH / methanol / Heating View Scheme
参考文献
Johnson, Martin R.; Seok, Won K.; Ibers, James A.
Journal of the American Chemical Society, 1991 , vol. 113, # 10 p. 3998 - 4000
反应条件
hydrogenchloride; tin
T=95°C; 1 h;
参考文献
Aldridge; Calder; Cunningham; Malik; Steed
Journal of Organometallic Chemistry, 2000 , vol. 614-615, p. 188 - 194
反应条件
tin in hydrogenchloride
参考文献
CHISSO Corporation; CHISSO Petrochemical Corporation
Patent: US2006/180791 A1, 2006 ;
反应条件
hydrogenchloride in water
参考文献
Nycomed Imaging AS
Patent: US5599522 A1, 1997 ;
反应条件
1: aq. NaOH / 70 °C
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Eiden; Schmiz
Archiv der Pharmazie, 1979 , vol. 312, # 9 p. 741 - 746
