2-(羧基甲氧基)苯甲酸合成路线 （共 29 条）
反应条件
sodium acetate in acetic acid 4 h; Heating;
参考文献
Carvalho, Christopher F.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1605 - 1612
反应条件
acetic anhydride in acetic acid 3 h; Reflux;
参考文献
Venkatesan, Aranapakam M.; Dos Santos; Ellingboe, John; Evrard, Deborah A.; Harrison, Boyd L.; Smith, Deborah L.; Scerni, Rosemary; Hornby, Geoffrey A.; Schechter, Lee E.; Andree, Terrence H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 824 - 827
反应条件
sulfuric acid; benzene
参考文献
Schroeder,D.C. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 586 - 591
反应条件
phosphorous pentoxide; copper(II) sulfate; sodium sulfate T=100°C; 4 h;
参考文献
Journal of the Indian Chemical Society, , vol. 64, # 1 p. 34 - 37
反应条件
1: With sodium acetate; acetic anhydride T=150°C; 4 h; 2: With hydrogenchloride; water 2 h; Heating / reflux;
参考文献
Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong
Patent: US2005/4162 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
US 20050004162 A1
反应条件
hydrogenchloride; potassium chlorate
参考文献
Ettel et al.
Collection of Czechoslovak Chemical Communications, 1950 , vol. 15, p. 1050,1064
反应条件
iodine; chlorine; acetic acid
参考文献
Ettel et al.
Collection of Czechoslovak Chemical Communications, 1950 , vol. 15, p. 1050,1064
反应条件
1: With sodium hydroxide; water
T=80°C; 4 h;
2: With hydrogenchloride
T=20°C;
参考文献
BEZWADA BIOMEDICAL, LLC
Patent: US2009/170927 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
1: With methanol; sodium hydroxide; water in tetrahydrofuran
24 h; Heating / reflux;
2: With hydrogenchloride; water
参考文献
WYETH
Patent: WO2004/99191 A2, 2004 ;
Location in patent: Page 46 ;
WO 2004/099191 A2
反应条件
sodium hydroxide in water
120 h; Heating / reflux;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2007/53131 A2, 2007 ;
Location in patent: Page/Page column 152 ;
WO 2007/053131 A2
