吡唑并[1,5-a]吡啶-2-甲酸合成路线 （共 8 条）
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
sulfuric acid T=80°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 17 p. 2691 - 2694
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=80°C; P=12001.2 Torr; 4 h;
参考文献
SCHWARZ PHARMA AG
Patent: WO2006/15737 A1, 2006 ;
Location in patent: Page/Page column 49 ;
反应条件
toluene-4-sulfonic acid 24 h; Heatingmolecular sieves;
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 1149 - 1152
反应条件
N-bromosuccinmide in chloroform T=20°C; 55 h;
参考文献
WO2006/15737 A1, ;
Page/Page column 48 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-20°C; 0.166667 h;
参考文献
Prante, Olaf; Tietze, Rainer; Hocke, Carsten; Loeber, Stefan; Huebner, Harald; Kuwert, Torsten; Gmeiner, Peter
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1800 - 1810
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran; toluene T=0 - 65°C; 5.5 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water; toluene 2 h; Reflux; 3: With sodium hydroxide in tetrahydrofuran; water; toluene
参考文献
LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, José Luis; CUBERES ALTISENT, Mª Rosa
Patent: WO2013/124341 A1, 2013 ;
Location in patent: Page/Page column 35-36 ;
反应条件
1: 1) oxalyl chloride / 1) toluene, 60 deg C, 4.5 h, 2) dichloromethane, -60 deg C to room temperature
2: 62 percent / anhydrous hydrazine / 16 h / Ambient temperature
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参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
