1,1,3,3-四甲基脲合成路线 （共 85 条）
反应条件
hydrogenchloride; N-Nitrosomorpholine; potassium iodide in dichloromethane; water T=22°C; 48 h;
参考文献
Tetrahedron, , vol. 39, # 3 p. 469 - 474
反应条件
1: N-tert-butoxycarbonyl-L-methionine With N-ethyl-N,N-diisopropylamine; HATU in dichloromethane 0.333333 h; 2: 5-Aminoindan-1-one in dichloromethane T=20°C; 20.0333 h;
参考文献
WO2006/27186 A1, ;
Page/Page column 28-29 ;
WO 2006/027186 A1
反应条件
tetraphosphorus decasulfide; triphenyl antimony oxide in benzene T=120°C; P=36752.9 Torr; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 57, # 28 p. 7339 - 7342
反应条件
iodine; potassium carbonate; palladium diacetate in acetonitrile T=95°C; P=2052 Torr; 3 h;
参考文献
Canadian Journal of Chemistry, , vol. 68, # 9 p. 1544 - 1547
反应条件
1: 9-methoxy-2,3-dimethyl-9-(2-methylphenyl)-7H-8,9-dihydro-pyrano[2,3-c]-imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=50°C; 2 h; 2: 3,3-difluoroazetidine hydrogen chloride salt in N,N-dimethyl-formamide T=50°C; 4 h;
参考文献
WO2007/141253 A1, ;
Page/Page column 67 ;
反应条件
dimethylaminomethyl-polystyrene in acetonitrile T=25°C; 24 h;
参考文献
Synthetic Communications, , vol. 14, # 11 p. 1073 - 1080
反应条件
1: 9-methoxy-2,3-dimethyl-9-phenyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine-6-carboxylic acid; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane 2 h; Heating / reflux; 2: anhydrous cyclopropylamine in dichloromethane T=20°C; 1.5 h;
参考文献
WO2007/141253 A1, ;
Page/Page column 63 ;
反应条件
1: 9-methoxy-2,3-dimethyl-9-phenyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine-6-carboxylic acid; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane 2 h; Heating / reflux; 2: trimethylene imine in dichloromethane T=20°C; 2 h;
参考文献
WO2007/141253 A1, ;
Page/Page column 62 ;
反应条件
in chloroform-d1 T=90°C; 20 h;
参考文献
Journal of Organometallic Chemistry, , vol. 419, # 1 p. 9 - 26
反应条件
1: 9-methoxy-2,3-dimethyl-9-phenyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine-6-carboxylic acid; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in dichloromethane 2 h; Heating / reflux; 2: methylamine in ethanol; dichloromethane T=20°C; 1 h;
参考文献
WO2007/141253 A1, ;
Page/Page column 61-62 ;
