4-甲基苯磺酰基-3-氯-1-丙醇合成路线 （共 33 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine 2 h; Inert atmosphereCooling with ice;
参考文献
Taguri, Tomonori; Yamakawa, Rei; Adachi, Yasushi; Mori, Kenji; Ando, Tetsu
Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 1 p. 119 - 124
参考文献
Rossander; Marvel
Journal of the American Chemical Society, 1928 , vol. 50, p. 1495
参考文献
Rossander; Marvel
Journal of the American Chemical Society, 1928 , vol. 50, p. 1495
参考文献
Rossander; Marvel
Journal of the American Chemical Society, 1928 , vol. 50, p. 1495
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 2 h; Product distribution / selectivity;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 3; 6-7 ;
反应条件
1: 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one With sodium hydride in DMF (N,N-dimethyl-formamide) 0.5 h; 2: 3-chloropropyl tosylate in DMF (N,N-dimethyl-formamide) T=50°C; 4 h;
参考文献
Wyeth
Patent: US2004/204402 A1, 2004 ;
Location in patent: Page/Page column 12-13 ;
US 20040204402 A1
参考文献
Rossander; Marvel
Journal of the American Chemical Society, 1928 , vol. 50, p. 1495
反应条件
tert-butylamine hydrobromide in tetrahydrofuran 0 deg C, 1 h, r.t., overnight;
参考文献
White; Whiteley
Synthesis, 1993 , # 11 p. 1141 - 1144
反应条件
1: (S)-2-methyl-1-butyl bromide With magnesium in tetrahydrofuran Inert atmosphere; 2: 3-chloropropyl tosylate With dilithium tetrachlorocuprate in tetrahydrofuran T=-70 - 20°C; Inert atmosphere;
参考文献
Mori, Kenji
Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 3 p. 595 - 600
反应条件
1: trimethylsilylacetylene With n-butyllithium in tetrahydrofuran 2: 3-chloropropyl tosylate With tert-butylamine hydrobromide in tetrahydrofuran T=0 - 20°C;
参考文献
Schaefer, Carsten; Scholz, Gerald; Gleiter, Rolf; Oeser, Thomas; Rominger, Frank
European Journal of Inorganic Chemistry, 2005 , # 7 p. 1274 - 1281
