2-氨基-6-氯-4-吡啶羧酸合成路线 （共 5 条）
反应条件
1: With ammonia in water T=165°C; P=14251.4 Torr; 8 h; Sealed tubeMicrowave irradiation; 2: With hydrogenchloride in water pH=3;
参考文献
GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David
Patent: WO2012/35055 A1, 2012 ;
Location in patent: Page/Page column 129-130 ;
WO 2012/035055 A1
参考文献
Journal of the Chemical Society, , vol. 71, p. 1082
Journal of the Chemical Society, , vol. 73, p. 441
反应条件
thionyl chloride 3 h; Reflux;
参考文献
Kyowa Hakko Kirin Co., Ltd.; SAWADA, Takashi; DANJO, Tomohiro; MOTOSAWA, Keiichi; FURUTA, Takayuki; ICHIOKA, Maki; SUGAWARA, Masamori; UESAKA, Noriaki
Patent: EP2671582 A1, 2013 ;
Location in patent: Paragraph 0552 ;
反应条件
1: With hydrogenchloride
12 h;
2: With sodium hydrogencarbonate
参考文献
BRACCO IMAGING S.P.A.; SWENSON, Rolf, E.; RAJU, Natarajan; ESTRELLA-JIMENEZ, Maria, E.; RAMALINGAM, Kondareddiar
Patent: WO2011/159864 A1, 2011 ;
Location in patent: Page/Page column 26 ;
参考文献
Sell; Dootson
Journal of the Chemical Society, 1900 , vol. 77, p. 237
