2-氯异烟酸合成路线

6313-54-82-氯异烟酸→6813-38-32,2'-联吡啶-4,4'-二甲酸

参考文献

Axiva GmbH
Patent: US6500956 B1, 2002 ;

6313-54-82-氯异烟酸+64-17-5乙醇→54453-93-92-氯异烟酸乙酯

参考文献

TANABE SEIYAKU CO., LTD.
Patent: WO2003/99787 A1, 2003 ;
Location in patent: Page 21 ;
WO 03/099787 A1

6313-54-82-氯异烟酸→54453-93-92-氯异烟酸乙酯

参考文献

Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 58 ;
US 6362336 B1

6313-54-82-氯异烟酸+79-37-8草酰氯→54453-93-92-氯异烟酸乙酯

参考文献

Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A

6313-54-82-氯异烟酸→639091-75-12-(Boc-氨基)异烟酸甲酯

参考文献

Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036

6313-54-82-氯异烟酸→65287-34-52-氯吡啶-4-酰氯

参考文献

Dyrager, Christine; Moellers, Linda Nilsson; Kjaell, Linda Karlsson; Alao, John Patrick; Diner, Peter; Wallner, Fredrik K.; Sunnerhagen, Per; Grotil, Morten
Journal of Medicinal Chemistry, 2011 , vol. 54, # 20 p. 7427 - 7431

6313-54-82-氯异烟酸+13602-12-5异烟酸-N-氧化物→65287-34-52-氯吡啶-4-酰氯

参考文献

Research Foundation Of State University Of New York
Patent: US5583148 A1, 1996 ;

6313-54-82-氯异烟酸+79-37-8草酰氯→65287-34-52-氯吡啶-4-酰氯

参考文献

SYNGENTA PARTICIPATIONS AG; PITTERNA, Thomas; CASSAYRE, Jerome Yves; CORSI, Camilla; MAIENFISCH, Peter
Patent: WO2010/9968 A1, 2010 ;
Location in patent: Page/Page column 31-32 ;

6313-54-82-氯异烟酸→639091-78-42-(Boc-氨基)-4-(氨甲基)吡啶

参考文献

Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036

6313-54-82-氯异烟酸+100-36-7N,N-二乙基乙二胺→1019383-26-6

参考文献

Greguric, Ivan; Taylor, Stephen R.; Denoyer, Delphine; Ballantyne, Patrice; Berghofer, Paula; Roselt, Peter; Pham, Tien Q.; Mattner, Filomena; Bourdier, Thomas; Neels, Oliver C.; Dorow, Donna S.; Loc'h, Christian; Hicks, Rodney J.; Katsifis, Andrew
Journal of Medicinal Chemistry, 2009 , vol. 52, # 17 p. 5299 - 5302