反应条件
1.1: α-chloroethyl chloroformiate / toluene / 3 h / Heating 1.2: 95 percent / methanol / 20 °C 2.1: 94 percent / Et3N / methanol / 0.5 h / 60 °C 3.1: 97 percent / LDA / tetrahydrofuran / 0.08 h / -78 °C 4.1: 70 percent / lithium borohydride; LiEt3BH / diethyl ether; tetrahydrofuran / 1 h / Heating 5.1: 70 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 20 °C 6.1: aq. KOH / 3 h / Heating View Scheme
参考文献
Jakobsen, Palle; Lundbeck, Jane M; Kristiansen, Marit; Breinholt, Jens; Demuth, Helle; Pawlas, Jan; Torres Candela, Maria P; Andersen, Birgitte; Westergaard, Niels; Lundgren, Karsten; Asano, Naoki
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 733 - 744