1: With Novozyme 435 (lipase acrylic resin from Candida antarctica) in tert-butyl methyl ether 3 h; Heating / reflux; 2: With hydrogenchloride in water 3: With sodium hydroxide in water pH=11; Purification / work up;
参考文献
PHARMACOPEIA, INC.
Patent: US2009/93472 A1, 2009 ;
Location in patent: Page/Page column 14 ;
US 20090093472 A1