2-氨基-6-硝基苯并噻唑合成路线 （共 40 条）
反应条件
hydrazine hydrate; monohydrazine sulfate in ethylene glycol T=120°C; 2 h;
参考文献
Byeon, Seong Rim; Jin, Yun Jung; Lim, Soo Jeong; Lee, Ji Hoon; Yoo, Kyung Ho; Shin, Kye Jung; Oh, Seung Jun; Kim, Dong Jin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4022 - 4025
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=2250.23 Torr; 2.5 h;
参考文献
US2009/233949 A1, ;
Page/Page column 10 ;
反应条件
1: aqueous H2SO4 / Diazotization.anschliessend Erwaermen 2: PCl5; POCl3 3: tin; aqueous HCl; acetic acid View Scheme
参考文献
Yakugaku Zasshi, , vol. 62, p. 47,51; dtsch. Ref. S. 19, 22
Chem.Abstr., , p. 609
反应条件
1: With phosphoric acid; sodium nitrite in water T=0°C; 1.5 h; 2: With copper(II) sulfate; sodium chloride in water T=0°C; 0.5 h;
参考文献
US2007/281945 A1, ;
Page/Page column 15 ;
US 20070281945 A1
反应条件
tetrahydrofuran; oxygen; nitrogen(II) oxide 6 h; Ambient temperature;
参考文献
Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Ohsawa, Akio
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1547 - 1549
反应条件
pyridine T=0 - 60°C; 2.16667 h;
参考文献
Nam, Nguyen Hai; Dung, Phan Thi Phuong; Thuong, Phuong Thien; Hien, Tran Thi
Medicinal Chemistry, 2010 , vol. 6, # 3 p. 159 - 164
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite in water T=20°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 42 ;
WO 2006/066173 A2
参考文献
Ambartsumova; Tashkhodzhaev; Antipin; Shakhidoyatov
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 11 p. 1397 - 1405
反应条件
potassium hydroxide in water; ethylene glycol
T=140°C; 24 h;
参考文献
Hirose, Wataru; Sato, Kousuke; Matsuda, Akira
European Journal of Organic Chemistry, 2011 , # 31 p. 6206 - 6217
