3-溴-1-丙醇合成路线

参考文献

TAKEDA PHARMACEUTICAL COMPANY LIMITED; FENG, Jun; KEUNG, Walter; LARDY, Matthew
Patent: WO2010/129848 A2, 2010 ;
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WO 2010/129848 A2

114774-44-6+

3963-62-02,2-二苯基乙胺+

93118-03-72-氯-3-(三氟甲基)苯甲醛+

627-18-93-溴-1-丙醇

405911-09-3GW3965

参考文献

Collins, Jon L.; Binz, Jane G.; Plunket, Kelli D.; Morgan, Daniel G.; Beaudet, Elizabeth J.; Whitney, Karl D.; Kliewer, Steven A.; Willson, Timothy M.; Fivush, Adam M.; Watson, Michael A.; Galardi, Cristin M.; Lewis, Michael C.; Moore, Linda B.; Parks, Derek J.; Wilson, Joan G.; Tippin, Tim K.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 10 p. 1963 - 1966

627-18-93-溴-1-丙醇

503-30-0三甲氧基酯

参考文献

Fujiwara, Masahiro; Hitomi, Kazuhisa; Baba, Akio; Matsuda, Haruo
Synthesis, 1990 , # 2 p. 106 - 109

627-18-93-溴-1-丙醇

503-30-0三甲氧基酯+

504-63-21,3-丙二醇

参考文献

Grob, Cyril A.; Waldner, Adrian
Helvetica Chimica Acta, 1980 , vol. 63, # 8 p. 2152 - 2158

122-60-1苯基缩水甘油醚+

627-18-93-溴-1-丙醇

503-30-0三甲氧基酯

参考文献

Bradley et al.
Journal of the Chemical Society, 1951 , p. 1589,1594

110-91-8吗啉+

627-18-93-溴-1-丙醇

4441-30-94-(3-羟丙基)吗啉

参考文献

Zeneca Limited
Patent: US6265411 B1, 2001 ;

109-02-4N-甲基吗啡啉+

627-18-93-溴-1-丙醇

4441-30-94-(3-羟丙基)吗啉

参考文献

American Cyanamid Company
Patent: US6355636 B1, 2002 ;
Location in patent: Page column 60 ;
US 6355636 B1

110-91-8吗啉+

627-18-93-溴-1-丙醇

4441-30-94-(3-羟丙基)吗啉

参考文献

Eli Lilly and Company
Patent: US4791106 A1, 1988 ;

627-18-93-溴-1-丙醇

503-30-0三甲氧基酯+

504-63-21,3-丙二醇

参考文献

Grob, Cyril A.; Waldner, Adrian
Helvetica Chimica Acta, 1980 , vol. 63, # 8 p. 2152 - 2158

106-48-9对氯苯酚+

627-18-93-溴-1-丙醇

18673-04-6

参考文献

Dorwald, Florencio Zaragoza; Andersen, Knud Erik; Sorensen, Jan Lindy
Patent: US2004/19039 A1, 2004 ;
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