反应条件
1: 2-chloroethoxycarbonyl chloride; (3R)-3-hydroxy-1-azabicyclo[2.2.2]octane With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 2: (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline in tetrahydrofuran T=20°C; 16 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/76116 A2, 2007 ;
Location in patent: Page/Page column 14 ;