1: 3-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; 1 h; 2: 2,6-Dibromopyridine With 1,2-bis-(diphenylphosphino)ethane; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=20°C; 18 h;
1: (trifluoromethyl)-trimethylsilane With silver fluoride in N,N-dimethyl-formamide T=20°C; 0.333333 h; 2: With copper in N,N-dimethyl-formamide 4 h; 3: 2,6-Dibromopyridine in N,N-dimethyl-formamide T=75°C; 4 h;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Yagupolskii, Yurii L.; Naumann, Dieter; Moeller, Angela
Journal of Fluorine Chemistry, 2012 , vol. 133, p. 67 - 71
1: 2,6-Dibromopyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: formic acid methyl ester in tetrahydrofuran T=-78°C; 2 h; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/21848 A1, 2006 ;
Location in patent: Page/Page column 30 ;
WO 2006/021848 A1
