3,3-二甲基-1-丁基酸酯合成路线 （共 65 条）
反应条件
1: pyridine / 16 h / Ambient temperature 2: dimethylsulfoxide / 6 h / 80 - 90 °C View Scheme
参考文献
Yokohama; Miwa; Aibara; Fujiwara; Matsumoto; Nakayama; Iwamoto; Mori; Moroi; Tsukada; Isoda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2391 - 2398
反应条件
sodium carbonate; [Ir(μ-Cl)(1,5-cyclooctadiene)]2 in benzene 12 h; Heating / reflux;
参考文献
Broughton, Howard Barff; Dally, Robert Dean; Durham, Timothy Barrett; Gonzalez-Garcia, Maria Rosario; Sa, Lilly; Hahn, Patric James; Henry, Kenneth James; Kohn, Todd Jonathan; McCarthy, James Ray; Shepherd, Timothy Alan; Erickson, Jon Andre; Bueno Melendo, Ana Belen
Patent: US2007/225267 A1, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
pyridine; phosphorus tribromide Bromination; 12 h; Heating;
参考文献
Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674
反应条件
sodium hypochlorite; 4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy free radical; Na2 tetraborate in water T=0°C; pH=8.3 - 8.4; 3 h; Aqueous hydrocarbonate buffer; Product distribution / selectivity;
参考文献
The NutraSweet Company
Patent: US6825384 B1, 2004 ;
Location in patent: Page column 11 ;
反应条件
potassium bromide; potassium iodide in dichloromethane; water
参考文献
The Nutrasweet Company
Patent: US5856584 A1, 1999 ;
反应条件
pyridinium chlorochromate in dichloromethane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5100889 A1, 1992 ;
反应条件
in dichloromethane; water; dimethyl sulfoxide
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5100889 A1, 1992 ;
反应条件
copper(II) oxide T=300°C; Gas phase;
参考文献
The NutraSweet Company
Patent: EP1186591 A2, 2002 ;
Location in patent: Page column 3 ;
反应条件
pyridine; water 1.) dioxane, RT, 2 h, 2.) dioxane, 15 min; Multistep reaction;
参考文献
Hengge, Alvan C.; Cleland
Journal of the American Chemical Society, 1991 , vol. 113, # 15 p. 5835 - 5841
反应条件
T=220°C; P=73550.8 Torr; Produkt5: Aethan;
参考文献
Ipatieff et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 553
