2,2,2-三氟乙基三氟甲烷磺酸酯合成路线

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+1068-90-2乙酰胺基丙二酸二乙酯→120097-64-52-乙酰胺基-2-(2,2,2-三氟乙基)丙二酸二乙酯

参考文献

Tetrahedron, , vol. 44, # 17 p. 5375 - 5387

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+63910-43-04-氯-5-甲氧基哒嗪-3(2H)-酮→1036934-84-5+14628-57-04-氯-5-甲氧基-2-甲基-2,3-二氢哒嗪-3-酮

参考文献

Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+41979-39-94-氧代哌啶酮盐酸盐→81363-14-61-(2,2,2-三氟乙基)-4-哌啶酮

参考文献

sanofi-aventis
Patent: US2008/269170 A1, 2008 ;
Location in patent: Page/Page column 52 ;

823197-37-16-(4-(甲基磺酰基)哌嗪-1-基)吡啶-3-醇+6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+79963-95-4三氟乙基全氟丁基磺酸酯→823197-38-2

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/822 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/000822 A1

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+88-75-5邻硝基苯酚→87014-28-61-硝基-2-(2,2,2-三氟乙氧基)-苯

参考文献

BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.
Patent: WO2014/8214 A1, 2014 ;
Location in patent: Paragraph 00500-00501 ;

2075-46-94-硝基吡唑+6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯→919278-38-94-硝基-1-(2,2,2-三氟乙基)-1H-吡唑

参考文献

Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+1761-61-15-溴水杨醛→923281-72-5

参考文献

TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 95 ;
WO 2007/015588 A1

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+57260-71-61-Boc-哌嗪→692058-21-24-(2,2,2-三氟乙基)哌嗪-1-羧酸叔丁酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 75 ;
WO 2004/041829 A1

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+105-53-3丙二酸二乙酯→99783-25-2

参考文献

Tsushima; Kawada; Ishihara; Uchida; Shiratori; Higaki; Hirata
Tetrahedron, 1988 , vol. 44, # 17 p. 5375 - 5387

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+490-79-92,5-二羟基苯甲酸→50778-57-92,2,2-三氟乙基2,5-二(2,2,2-三氟乙氧基)苯甲酸酯

参考文献

Riker Laboratories, Inc.
Patent: US3996280 A1, 1976 ;