3-氧代哌啶-1-羧酸乙酯合成路线 （共 17 条）
反应条件
1: benzene / 1 h / 25 °C 2: 50 percent / acetonitrile / 48 h / Heating 3: 89 percent / benzene / Heating 4: 72 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Brubaker; Colley Jr.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1528 - 1531
反应条件
triethylamine in chloroform
T=25°C; 1 h;
参考文献
Brubaker; Colley Jr.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1528 - 1531
反应条件
hydrogenchloride; triethylamine in chloroform
参考文献
SmithKline Corporation
Patent: US4005208 A1, 1977 ;
反应条件
triethylsilane; titanium tetrachloride in dichloromethane
参考文献
Chen Ling-Ching; Wang, Eng-Chi; Lin, Jen-Hom; Wu, Shihn-Sheng
Heterocycles, 1984 , vol. 22, # 12 p. 2769 - 2773
参考文献
Research Corporation Technologies, Inc.
Patent: US4973593 A1, 1990 ;
US 4973593 A
反应条件
jones' reagent in acetone
0.25 h; Yield given;
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
1: 80 percent / H2 / 5percent Pd/C / Ambient temperature
2: 75 percent / K2CO3 / H2O / 3 h / Ambient temperature
3: 73 percent / NaBH4 / ethanol / Ambient temperature
4: 80 percent / 1M TiCl4, Et3SiH / CH2Cl2
View Scheme
参考文献
Chen Ling-Ching; Wang, Eng-Chi; Lin, Jen-Hom; Wu, Shihn-Sheng
Heterocycles, 1984 , vol. 22, # 12 p. 2769 - 2773
反应条件
2: 36 percent / Na2CO3 / H2O / 12 h / 0 °C
3: 35 percent / t-BuOK / toluene / 1.5 h / 0 °C
4: aq. HCl / 20 h / Heating
View Scheme
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
1: 35 percent / t-BuOK / toluene / 1.5 h / 0 °C
2: aq. HCl / 20 h / Heating
View Scheme
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
反应条件
1: 36 percent / Na2CO3 / H2O / 12 h / 0 °C
2: 35 percent / t-BuOK / toluene / 1.5 h / 0 °C
3: aq. HCl / 20 h / Heating
View Scheme
参考文献
Garst, Michael E.; Bonfiglio, John N.; Grudoski, David A.; Marks, Jeffrey
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2307 - 2315
