6-溴-咪唑并[1,2-a]吡啶合成路线 （共 12 条）
反应条件
1: in ethanol; water 3 h; Reflux; 2: With sodium hydrogencarbonate in water
参考文献
Calitor Sciences, LLC; Xi, Ning
Patent: US2014/134133 A1, 2014 ;
Location in patent: Paragraph 0399 ;
反应条件
hydrogenchloride; sodium hydroxide; sodium acetate; sodium in water; ethyl alcohol water
反应条件
in ethanol; water 18 h; Heating / reflux;
参考文献
WO2009/50183 A2, ;
Page/Page column 119 ;
参考文献
US2014/134133 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; sodium hydrogencarbonate 1) H2O, a) r.t., b) 80 deg C, 2) r.t.; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567
反应条件
2: 70.5 percent / ozone, conc. HCl / H2O; methanol / -5 - 0 °C 3: 74.5 percent / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567
反应条件
ozone; sodium sulfite 1.) AcOEt, -60 deg C, 7 min, 2.) AcOEt; Yield given. Multistep reaction;
参考文献
Yamanaka; Suda; Yoneda; Ohhara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 666 - 674
反应条件
nitric acid in sulfuric acid
参考文献
Merck and Co., Inc.
Patent: US4177274 A1, 1979 ;
Title/Abstract Full Text Show Details
Merck and Co., Inc.
Patent: US4237300 A1, 1980 ;
反应条件
bromine in acetic acid T=20°C; 1 h;
参考文献
NOVARTIS AG
Patent: WO2009/50183 A2, 2009 ;
Location in patent: Page/Page column 119 ;
反应条件
2: 70.5 percent / ozone, conc. HCl / H2O; methanol / -5 - 0 °C 3: 74.5 percent / dimethylformamide / 1 h / 80 °C 4: 50.9 percent / NaOCH3 / dimethylformamide / 12 h / 80 - 90 °C View Scheme
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
