3-(4-甲氧基苯基)-1-甲基-1H-吡唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Han, Young Taek; Kim, Kyeojin; Choi, Gyeong-In; An, Hongchan; Son, Dohyun; Kim, Hee; Ha, Hee-Jin; Son, Jun-Hyeng; Chung, Suk-Jae; Park, Hyun-Ju; Lee, Jeewoo; Suh, Young-Ger
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 128 - 142
反应条件
in ethanol
T=80°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/49578 A1, 2005 ;
Location in patent: Page/Page column 138 ;
WO 2005/049578 A1
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C
1.2: 1 h / 20 °C
1.3: 3 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
参考文献
Han, Young Taek; Kim, Kyeojin; Choi, Gyeong-In; An, Hongchan; Son, Dohyun; Kim, Hee; Ha, Hee-Jin; Son, Jun-Hyeng; Chung, Suk-Jae; Park, Hyun-Ju; Lee, Jeewoo; Suh, Young-Ger
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 128 - 142
