2-(4-硝基苯基)乙酰肼合成路线 （共 4 条）
反应条件
1: HCl; water; NaNO2 3: hydrochloric acid View Scheme
参考文献
Curtius
Journal fuer Praktische Chemie (Leipzig), 1914 , vol. <2> 89, p. 500,512
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 91, p. 7
反应条件
hydrazine in dichloromethane
T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 88-89 ;
WO 2007/075567 A1
反应条件
1: With thionyl chloride
T=20°C;
2: With hydrazine hydrate in ethanol; water
T=80°C; 0.75 h;
参考文献
Elsinghorst, Paul W.; Haertig, Wolfgang; Goldhammer, Simone; Grosche, Jens; Guetschow, Michael
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 19 p. 3940 - 3946
反应条件
hydrazine hydrate
T=100°C;
参考文献
Curtius
Journal fuer Praktische Chemie (Leipzig), 1914 , vol. <2> 89, p. 500,512
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 91, p. 7
