2-(2-噻吩基)乙基甲烷磺酸酯合成路线 （共 9 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water T=40°C; 5 h;
参考文献
Albanese, Domenico; Ghidoli, Cristina; Zenoni, Maurizio
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 736 - 739
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: 85 percent / dimethylformamide / 6 h / 60 °C 2: 89 percent / TBTH; Ni(diphenylphosphinoethane)Cl2 / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Malanga, Corrado; Mannucci, Serena; Lardicci, Luciano
Journal of Chemical Research, Miniprint, 2000 , # 6 p. 701 - 715
反应条件
triethylamine in dichloromethane
T=25°C; 2.25 h; Cooling with ice;
参考文献
Albanese, Domenico; Ghidoli, Cristina; Zenoni, Maurizio
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 736 - 739
反应条件
triethylamine in dichloromethane; di-isopropyl ether
参考文献
Janssen Pharmaceutica N.V.
Patent: US3998834 A1, 1976 ;
Title/Abstract Full Text Show Details
Janssen Pharmaceutica N.V.
Patent: US4179569 A1, 1979 ;
反应条件
in dichloromethane; di-isopropyl ether
参考文献
Janssen Pharmaceutica N.V.
Patent: US5461050 A1, 1995 ;
参考文献
Janssen Pharmaceutica N.V.
Patent: US4179569 A1, 1979 ;
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide in ethanol; water
参考文献
American Cyanamid Company
Patent: US4185115 A1, 1980 ;
反应条件
potassium carbonate; triethylamine; potassium iodide in acetonitrile
T=20°C; Reflux;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
