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| CAS号 : | 5402-55-1 |
精确质量 : | 128.03000 |
| 分子式 : | C6H8OS |
logP : | 1.28290 |
| 分子量 : | 128.19200 |
PSA : | 48.47000 |
噻吩乙醇 | |
2-Thiopheneethanol | |
5402-55-1 | |
C6H8OS | |
128.19200 | |
48.47000 | |
1.28290 | |
128.03000 |
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n20/D 1.551(lit.)
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透明无色至淡色的液体
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214 °F
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108-109 °C13 mm Hg(lit.)
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1.153 g/mL at 25 °C(lit.)
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slightly soluble
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Stable under normal temperatures and pressures.
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Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
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3
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29349990
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S23-S24/25
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Xi
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R36/37/38
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2933990090
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2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% | |
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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暂时无法加载合成路线，请稍后刷新重试 |
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<p>1.制法: 于装有搅拌器、温度计、滴液漏斗、回流冷凝器的反应瓶中,加入干燥的镁屑38.5g(1.58mol),无水THP100mL,一粒碘。慢慢滴入由2-溴噻吩<br>(2)250g(1.5mol)和1000mLTHF配成的溶液,先加入约40mL,温热引发反应。引发后搅拌下滴加其余的2-溴噻吩溶液,保持内温45℃左右,约4h加完。加完后继续搅拌反应2h。冷至5℃,慢慢滴加环氧乙烷70.4(1.6mol)溶于200mLTHF且冷至5℃的溶液,约4h加完,室温搅拌反应6h。冰水浴冷至5℃,滴加200mL饱和氯化铵溶液而后于35～40℃保温反应0.5h。倾出上层溶液,下次粘稠物用THF提取两次,合并THF溶液,依次用饱和碳酸钠溶液、饱和食盐水洗涤,无水硫酸钠干燥。减压蒸出THF,而后减压分馏,收集102℃/0.4～0.66kPa的馏分,得2-噻吩乙醇<br>(1),收率70%～75%。 </p> | |
<p>用作抗血栓药噻氯匹啶中间体。</p> |
