4-(3-羟基-1-丙炔)苯甲酸甲酯合成路线 （共 9 条）
反应条件
manganese(IV) oxide; potassium hydroxide in benzene 0.25 h; Ambient temperature;
参考文献
Bumagin, N. A.; Ponomarev, A. B.; Beletskaya, I. P.
Doklady Chemistry, 1985 , vol. 283, p. 212 - 214
Dokl. Akad. Nauk SSSR Ser. Khim., 1985 , vol. 283, # 3 p. 630 - 633
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
反应条件
1: 95 percent / H2 / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr 2: 95 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, overnight View Scheme
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
反应条件
copper(l) iodide; (Ph3P)2Pd(Ph)(I); triethylamine in chloroform
T=50°C; 0.25 h;
参考文献
Bumagin, N. A.; Ponomarev, A. B.; Beletskaya, I. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 7 p. 1433 - 1438
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 7 p. 1561 - 1566
反应条件
copper monoiodide in water; diethylamine
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5739141 A1, 1998 ;
反应条件
triphenylphosphine; palladium(II) chloride in ethyl acetate; diethylamine
参考文献
Eli Lilly and Company
Patent: US5426110 A1, 1995 ;
US 5426110 A
反应条件
copper(l) iodide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in benzene
T=70°C; 2 h;
参考文献
Bumagin; Ponomaryov; Beletskaya
Synthesis, 1984 , vol. NO. 9, p. 728 - 729
反应条件
copper(l) iodide; triethylamine; triphenylphosphine; PdCl2(PPh3)
Substitution; 1 h; Heating;
参考文献
Suchy, Petr; Dvorak, Dalimil; Havelkova, Martina
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 1 p. 119 - 129
反应条件
(i) Py, (ii) aq. HCl; Multistep reaction;
参考文献
Harris,M.A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 1612 - 1615
