2-硝基苯并[b]噻吩-3-甲腈合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol 24 h;
参考文献
GLAXO GROUP LIMITED; BULLION, Ann, Marie; BUSCH-PETERSEN, Jakob; EVANS, Brian; NEIPP, Christopher, E.; MCCLELAND, Brent, W.; NEVINS, Neysa; WALL, Michael, D.
Patent: WO2011/25799 A1, 2011 ;
Location in patent: Page/Page column 105 ;
WO 2011/025799 A1
反应条件
in DMF (N,N-dimethyl-formamide)
T=120°C; 3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14895 A1, 2004 ;
Location in patent: Page 104 ;
WO 2004/014895 A1
反应条件
in N,N-dimethyl-formamide
T=140°C; 1 h;
参考文献
GLAXO GROUP LIMITED; BULLION, Ann, Marie; BUSCH-PETERSEN, Jakob; EVANS, Brian; NEIPP, Christopher, E.; MCCLELAND, Brent, W.; NEVINS, Neysa; WALL, Michael, D.
Patent: WO2011/25799 A1, 2011 ;
Location in patent: Page/Page column 105 ;
WO 2011/025799 A1
反应条件
1: nitronium tetrafluoroborate / dichloromethane / 2.17 h / 0 °C
2: N,N-dimethyl-formamide / 1 h / 140 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; BULLION, Ann, Marie; BUSCH-PETERSEN, Jakob; EVANS, Brian; NEIPP, Christopher, E.; MCCLELAND, Brent, W.; NEVINS, Neysa; WALL, Michael, D.
Patent: WO2011/25799 A1, 2011 ;
WO 2011/025799 A1
