反应条件
1: 81 percent / aq. HNO3 / propionic acid / 0.25 h / 125 °C 2: SOCl2; DMF / CH2Cl2 / 3 h / Heating 3: Et3N / CH2Cl2 / 0.25 h / Heating 4: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 5: 1 h / Heating 6: peracetic acid / ethanol / 2.5 h / 60 °C 7: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 8: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme
参考文献
Gerster, John F.; Lindstrom, Kyle J.; Miller, Richard L.; Tomai, Mark A.; Birmachu, Woubalem; Bomersine, Shannon N.; Gibson, Shiela J.; Imbertson, Linda M.; Jacobson, Joel R.; Knafla, Roy T.; Maye, Peter V.; Nikolaides, Nickolas; Oneyemi, Folakemi Y.; Parkhurst, Gwen J.; Pecore, Sharon E.; Reiter, Michael J.; Scribner, Lisa S.; Testerman, Tracy L.; Thompson, Natalie J.; Wagner, Tammy L.; Weeks, Charles E.; Andre, Jean-Denis; Lagain, Daniel; Bastard, Yvon; Lupu, Michel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3481 - 3491