2-乙酰基-4-戊酸乙酯合成路线 （共 58 条）
反应条件
NaOEt in ethanol; water
参考文献
American Home Products Corporation
Patent: US5336677 A1, 1994 ;
参考文献
Hach
Chemicke Listy, 1951 , vol. 45, p. 459
Chem.Abstr., 1952 , p. 7573
反应条件
1: 1.) aq. 10 percent sodium hydroxide, 2.) conc. hydrochloric acid / 1.) reflux, 20 h, 2.) 0 deg C, pH 6
2: LAH / diethyl ether / 1 h / Ambient temperature
3: triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 30 min
View Scheme
参考文献
Becker; Haddad
Tetrahedron, 1993 , vol. 49, # 4 p. 947 - 964
反应条件
calcium hydroxide powder; sulfuric acid
1.) H2O, EtOH, 40 deg C, 48 h, 2.) H2O, EtOH, 70 deg C, pH=2, 24 h; Yield given. Multistep reaction;
参考文献
Botta, M.; Cavalieri, M.; Ceci, D.; Angelis, F. De; Finizia, G.; Nicoletti, R.
Tetrahedron, 1984 , vol. 40, # 17 p. 3313 - 3320
反应条件
1.1: 37.8 g / aq. NaOH / 3 h / 60 °C
2.1: 66 percent / pTosOH / toluene / Heating
3.1: BH3*THF / tetrahydrofuran / 3 h / 20 °C
3.2: 91 percent / aq. H2O2; aq. NaOH / 1 h / 20 °C
4.1: 90 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Backes, J. Rene; Koert, Ulrich
European Journal of Organic Chemistry, 2006 , # 12 p. 2777 - 2785
反应条件
4-(N,N-dimethlyamino)pyridine in toluene
Heating;
参考文献
Stefani, Helio A.; Costa, Iguatemi M.; De O. Silva, Diogo; Menezes, Paulo H.; Rodrigues, Alessandro
Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 171-172, p. 141 - 152
反应条件
1: 1.) aq. 10 percent sodium hydroxide, 2.) conc. hydrochloric acid / 1.) reflux, 20 h, 2.) 0 deg C, pH 6
2: LAH / diethyl ether / 1 h / Ambient temperature
3: triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 30 min
4: lithium bromide / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Becker; Haddad
Tetrahedron, 1993 , vol. 49, # 4 p. 947 - 964
反应条件
4-(N,N-dimethlyamino)pyridine in toluene
Heating;
参考文献
Stefani, Helio A.; Costa, Iguatemi M.; De O. Silva, Diogo; Menezes, Paulo H.; Rodrigues, Alessandro
Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 171-172, p. 141 - 152
